| Registro completo |
| Provedor de dados: |
BJMBR
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| País: |
Brazil
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| Título: |
Cytokine profile and pathology in human leishmaniasis
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| Autores: |
Ribeiro-de-Jesus,A.
Almeida,R.P.
Lessa,H.
Bacellar,O.
Carvalho,E.M.
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| Data: |
1998-01-01
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| Ano: |
1998
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| Palavras-chave: |
Leishmaniasis
Human leishmaniasis
Cytokines
Pathology
Immunological responses
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| Resumo: |
The clinical spectrum of leishmaniasis and control of the infection are influenced by the parasite-host relationship. The role of cellular immune responses of the Th1 type in the protection against disease in experimental and human leishmaniasis is well established. In humans, production of IFN-<FONT FACE="Symbol">g</font> is associated with the control of infection in children infected by Leishmania chagasi. In visceral leishmaniasis, an impairment in IFN-<FONT FACE="Symbol">g</font> production and high IL-4 and IL-10 levels (Th2 cytokines) are observed in antigen-stimulated peripheral blood mononuclear cells (PBMC). Moreover, IL-12 restores IFN-<FONT FACE="Symbol">g</font> production and enhances the cytotoxic response. IL-10 is the cytokine involved in down-regulation of IFN-<FONT FACE="Symbol">g</font> production, since anti-IL-10 monoclonal antibody (mAb) restores in vitro IFN-<FONT FACE="Symbol">g</font> production and lymphoproliferative responses, and IL-10 abrogates the effect of IL-12. In cutaneous and mucosal leishmaniasis, high levels of IFN-<FONT FACE="Symbol">g</font> are found in L. amazonensis-stimulated PBMC. However, low or absent IFN-<FONT FACE="Symbol">g</font> levels were observed in antigen-stimulated PBMC from 50% of subjects with less than 60 days of disease (24 ± 26 pg/ml). This response was restored by IL-12 (308 ± 342 pg/ml) and anti-IL-10 mAb (380 ± 245 pg/ml) (P<0.05). Later during the disease, high levels of IFN-<FONT FACE="Symbol">g</font> and TNF-<FONT FACE="Symbol">a</font> are produced both in cutaneous and mucosal leishmaniasis. After treatment there is a decrease in TNF-<FONT FACE="Symbol">a</font> levels (366 ± 224 pg/ml before treatment vs 142 ± 107 pg/ml after treatment, P = 0.02). Although production of IFN-<FONT FACE="Symbol">g</font> and TNF-<FONT FACE="Symbol">a</font> might be involved in the control of parasite multiplication in the early phases of Leishmania infection, these cytokines might also be involved in the tissue damage seen in tegumentary leishmaniasis
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100020
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| Editor: |
Associação Brasileira de Divulgação Científica
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| Relação: |
10.1590/S0100-879X1998000100020
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Medical and Biological Research v.31 n.1 1998
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| Direitos: |
info:eu-repo/semantics/openAccess
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