| Registro completo |
| Provedor de dados: |
BJMBR
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| País: |
Brazil
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| Título: |
In vitro antimicrobial activity of a new series of 1,4-naphthoquinones
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| Autores: |
Riffel,A.
Medina,L.F.
Stefani,V.
Santos,R.C.
Bizani,D.
Brandelli,A.
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| Data: |
2002-07-01
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| Ano: |
2002
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| Palavras-chave: |
5-Amino-8-hydroxy-1
4-naphthoquinone Antimicrobial agent Staphylococcus aureus Quinone Naphthazarin 5-Acetamido-8-hydroxy-1
4-naphthoquinone 2
3-Diamino-1
4-naphthoquinone
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| Resumo: |
The antibacterial activity of a series of 1,4-naphthoquinones was demonstrated. Disk diffusion tests were carried out against several Gram-positive and Gram-negative bacteria. The compound 5-amino-8-hydroxy-1,4-naphthoquinone was the most effective, presenting inhibition zones measuring 20 mm against staphylococci, streptococci and bacilli at 50 µg/ml. Methicillin-resistant Staphylococcus aureus and several clinical isolates of this bacterium were also inhibited. Naphthazarin, 5-acetamido-8-hydroxy-1,4-naphthoquinone, and 2,3-diamino-1,4-naphthoquinone were the next most active compounds. The minimal inhibitory concentration of the active compounds was determined against S. aureus, ranging from 30 to 125 µg/ml. All compounds presented a minimal bactericidal concentration higher than 500 µg/ml, indicating that their effect was bacteriostatic. The EC50, defined as the drug concentration that produces 50% of maximal effect, was 8 µg/ml for 5-amino-8-hydroxy-1,4-naphthoquinone against S. aureus, S. intermedius, and S. epidermidis. These results indicate an effective in vitro activity of 5-amino-8-hydroxy-1,4-naphthoquinone and encourage further studies for its application in antibiotic therapy.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000700008
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| Editor: |
Associação Brasileira de Divulgação Científica
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| Relação: |
10.1590/S0100-879X2002000700008
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Medical and Biological Research v.35 n.7 2002
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| Direitos: |
info:eu-repo/semantics/openAccess
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