| Registro completo |
| Provedor de dados: |
BJMBR
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| País: |
Brazil
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| Título: |
RNA and DNA aptamers as potential tools to prevent cell adhesion in disease
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| Autores: |
Ulrich,H.
Alves,M.J.M.
Colli,W.
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| Data: |
2001-03-01
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| Ano: |
2001
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| Palavras-chave: |
SELEX
Aptamers
Cell adhesion
Cell invasion
Trypanosoma cruzi
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| Resumo: |
Recent research has shown that receptor-ligand interactions between surfaces of communicating cells are necessary prerequisites for cell proliferation, cell differentiation and immune defense. Cell-adhesion events have also been proposed for pathological conditions such as cancer growth, metastasis, and host-cell invasion by parasites such as Trypanosoma cruzi. RNA and DNA aptamers (aptus = Latin, fit) that have been selected from combinatorial nucleic acid libraries are capable of binding to cell-adhesion receptors leading to a halt in cellular processes induced by outside signals as a consequence of blockage of receptor-ligand interactions. We outline here a novel approach using RNA aptamers that bind to T. cruzi receptors and interrupt host-cell invasion in analogy to existing procedures of blocking selectin adhesion and function in vitro and in vivo.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000300002
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| Editor: |
Associação Brasileira de Divulgação Científica
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| Relação: |
10.1590/S0100-879X2001000300002
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Medical and Biological Research v.34 n.3 2001
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| Direitos: |
info:eu-repo/semantics/openAccess
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