Registro completo |
Provedor de dados: |
56
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País: |
Brazil
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Título: |
Long-term, regular remote ischemic preconditioning improves endothelial function in patients with coronary heart disease
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Autores: |
Liang,Y.
Li,Y.P.
He,F.
Liu,X.Q.
Zhang,J.Y.
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Data: |
2015-06-01
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Ano: |
2015
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Palavras-chave: |
Remote ischemic preconditioning
Endothelial function
Coronary heart disease
STAT-3
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Resumo: |
Remote ischemic preconditioning (RIPre) can prevent myocardial injury. The purpose of this study was to assess the beneficial effects of long-term regular RIPre on human arteries. Forty patients scheduled for coronary artery bypass graft (CABG) surgery were assigned randomly to a RIPre group (n=20) or coronary heart disease (CHD) group (n=20). Twenty patients scheduled for mastectomy were enrolled as a control group. RIPre was achieved by occluding arterial blood flow 5 min with a mercury sphygmomanometer followed by a 5-min reperfusion period, and this was repeated 4 times. The RIPre procedure was repeated 3 times a day for 20 days. In all patients, arterial fragments discarded during surgery were collected to evaluate endothelial function by flow-mediated dilation (FMD), CD34+ monocyte count, and endothelial nitric oxide synthase (eNOS expression). Phosphorylation levels of STAT-3 and Akt were also assayed to explore the underlying mechanisms. Compared with the CHD group, long-term regular RIPre significantly improved FMD after 20 days (8.5±2.4 vs 4.9±4.2%, P<0.05) and significantly reduced troponin after CABG surgery (0.72±0.31 and 1.64±0.19, P<0.05). RIPre activated STAT-3 and increased CD34+ endothelial progenitor cell counts found in arteries. Long-term, regular RIPre improved endothelial function in patients with CHD, possibly due to STAT-3 activation, and this may have led to an increase in endothelial progenitor cells.
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Tipo: |
Info:eu-repo/semantics/article
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Idioma: |
Inglês
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Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000600568
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Editor: |
Associação Brasileira de Divulgação Científica
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Relação: |
10.1590/1414-431x20144452
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Formato: |
text/html
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Fonte: |
Brazilian Journal of Medical and Biological Research v.48 n.6 2015
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Direitos: |
info:eu-repo/semantics/openAccess
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