| Registro completo |
| Provedor de dados: |
BJM
|
| País: |
Brazil
|
| Título: |
An investigation on in vitro and in vivo antimicrobial properties of the antidepressant: amitriptyline hydrochloride
|
| Autores: |
Mandal,Anurup
Sinha,Chandrima
Jena,Aditya Kumar
Ghosh,Soma
Samanta,Amalesh
|
| Data: |
2010-10-01
|
| Ano: |
2010
|
| Palavras-chave: |
Amitriptyline hydrochloride
Antimicrobial activity
Non antibiotics
|
| Resumo: |
The antidepressant drug amitriptyline hydrochloride was obtained in a dry powder form and was screened against 253 strains of bacteria which included 72 Gram positive and 181 Gram negative bacteria and against 5 fungal strains. The minimum inhibitory concentration (MIC) was determined by inoculating a loopful of an overnight peptone water culture of the organism on nutrient agar plates containing increasing concentrations of amitriptyline hydrochloride (0, 10 µg/mL, 25 µg/mL, 50 µg/mL, 100 µg/mL, 200 µg/mL). Amitriptyline hydrochloride exhibited significant action against both Gram positive and Gram negative bacteria at 25-200 µg/mL. In the in vivo studies it was seen that amitriptyline hydrochloride at a concentration of 25 µg/g and 30 µg/g body weight of mouse offered significant protection to Swiss strain of white mice when challenged with 50 median lethal dose (MLD) of a virulent strain of Salmonella typhimurium NCTC 74. The in vivo data were highly significant (p<0.001) according to the chi-square test.
|
| Tipo: |
Info:eu-repo/semantics/article
|
| Idioma: |
Inglês
|
| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822010000300014
|
| Editor: |
Sociedade Brasileira de Microbiologia
|
| Relação: |
10.1590/S1517-83822010000300014
|
| Formato: |
text/html
|
| Fonte: |
Brazilian Journal of Microbiology v.41 n.3 2010
|
| Direitos: |
info:eu-repo/semantics/openAccess
|
