| Registro completo |
| Provedor de dados: |
BJM
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| País: |
Brazil
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| Título: |
Evolution of equine influenza viruses (H3N8) during a Brazilian outbreak, 2015
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| Autores: |
Favaro,Patricia Filippsen
Fernandes,Wilson Roberto
Reischak,Dilmara
Brandão,Paulo Eduardo
Silva,Sheila Oliveira de Souza
Richtzenhain,Leonardo José
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| Data: |
2018-06-01
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| Ano: |
2018
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| Palavras-chave: |
Equine influenza
H3N8
Hemagglutinin
Neuraminidase
Evolutionary analysis
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| Resumo: |
Abstract Equine influenza is one of the major respiratory infectious diseases in horses. An equine influenza virus outbreak was identified in vaccinated and unvaccinated horses in a veterinary school hospital in São Paulo, SP, Brazil, in September 2015. The twelve equine influenza viruses isolated belonged to Florida Clade 1. The hemagglutinin and neuraminidase amino acid sequences were compared with the recent isolates from North and South America and the World Organisation for Animal Health recommended Florida Clade 1 vaccine strain. The hemagglutinin amino acid sequences had nine substitutions, compared with the vaccine strain. Two of them were in antigenic site A (A138S and G142R), one in antigenic site E (R62K) and another not in antigenic site (K304E). The four substitutions changed the hydrophobicity of hemagglutinin. Three distinct genetic variants were identified during the outbreak. Eleven variants were found in four quasispecies, which suggests the equine influenza virus evolved during the outbreak. The use of an out of date vaccine strain or updated vaccines without the production of protective antibody titers might be the major contributing factors on virus dissemination during this outbreak.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000200336
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| Editor: |
Sociedade Brasileira de Microbiologia
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| Relação: |
10.1016/j.bjm.2017.07.003
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Microbiology v.49 n.2 2018
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| Direitos: |
info:eu-repo/semantics/openAccess
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