| Registro completo |
| Provedor de dados: |
BJPS
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| País: |
Brazil
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| Título: |
Dissolution test optimization for meloxicam in the tablet pharmaceutical form
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| Autores: |
Oliveira,Érika de Fátima Silva
Azevedo,Roberta de Cássia Pimentel
Bonfilio,Rudy
Oliveira,Diego Borges de
Ribeiro,Gislaine Pereira
Araújo,Magali Benjamim de
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| Data: |
2009-03-01
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| Ano: |
2009
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| Palavras-chave: |
Meloxicam/dissolution
Dissolution kinetics
Tablet pharmaceutical forms/dissolution test
Spectrophotometry
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| Resumo: |
Meloxicam is a broadly used drug in the therapeutics for the osteoarthritis and rheumatoid arthritis treatments in adults, and it is available in the Brazilian market, as tablet and capsule pharmaceutical forms. The present work aimed to establish conditions for accomplishment of the dissolution test of 15 mg meloxicam tablets (A and B test products), compared with the reference product, since there is no monograph about dissolution assays for meloxicam in official summaries. To optimize the conditions several parameters were tested and, according to obtained results, the use of pH 7.5 phosphate buffer (900mL, at 37 ± 0.5ºC) as dissolution medium, paddle method (apparatus 2), stirring speed of the dissolution medium at 100 rpm and collect time of 60 minutes were considered satisfactory. The samples were quantified by UV spectrophotometric method at 362 nm. The products presented kinetics of first-order. Dissolution efficiency values were of 83.25, 83.73 and 88.10% for the A, B and reference products, respectively. Factors f1 and f2 were calculated and similarity of the tested medicines was demonstrated. The dissolution test was validated presenting selectivity, linearity, precision and accuracy within of the acceptance criteria.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000100008
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| Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
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| Relação: |
10.1590/S1984-82502009000100008
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.45 n.1 2009
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| Direitos: |
info:eu-repo/semantics/openAccess
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