| Registro completo |
| Provedor de dados: |
BJPS
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| País: |
Brazil
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| Título: |
Simultaneous RP-HPLC determination of sparfloxacin and dexamethasone in pharmaceutical formulations
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| Autores: |
Razzaq,Syed Naeem
Ashfaq,Muhammad
Mariam,Irfana
Khan,Islam Ullah
Razzaq,Syed Saleem
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| Data: |
2013-06-01
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| Ano: |
2013
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| Palavras-chave: |
RP-HPLC
Sparfloxacin
Dexamethasone
Degradation products
Stability studies
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| Resumo: |
The present study describes the development and subsequent validation of simple and accurate stability indicating RP-HPLC method for the determination of sparfloxacin and dexamethasone in pharmaceutical formulations in the presence of their stress-induced degradation products. Both the drugs and their stress-induced degradation products were separated within 10 minutes using C8 column and mixture of methanol and 0.02 M phosphate buffer pH 3.0 (60:40 v/v, respectively) as mobile phase at 270 nm using diode array detector. Regression analysis showed linearity in the range of 15-105 µg/mL for sparfloxacin and 5-35 µg/mL for dexamethasone. All the analytes were adequately resolved with acceptable tailing. Peak purity of the two drugs was also greater than 0.9999, showing no co-elution peaks. The developed method was applied for simultaneous determination of sparfloxacin and dexamethasone in pharmaceutical formulations for stability studies.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000200012
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| Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
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| Relação: |
10.1590/S1984-82502013000200012
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.49 n.2 2013
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| Direitos: |
info:eu-repo/semantics/openAccess
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