| Registro completo |
| Provedor de dados: |
BJPS
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| País: |
Brazil
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| Título: |
Evaluation of the impact of orally administered carbohydrates on postprandial blood glucose levels in different pre-clinical models
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| Autores: |
Marques,Any de Castro Ruiz
Schiavon,Fabiana Percinoto Monteiro
Travassos,Patricia Batista
Eik,Vanessa Fontana
Godoy,Guilherme
Schamber,Christiano Rodrigues
Bazotte,Roberto Barbosa
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| Data: |
2016-12-01
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| Ano: |
2016
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| Palavras-chave: |
Glycemic index/study
Glycemic index/oral administration
Glycemic load
Interstitial glucose
Real time continuous glucose monitoring system
Carbohydrates/posprandial glucose levels/rats.
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| Resumo: |
ABSTRACT We developed a pre-clinical model in which to evaluate the impact of orally administered carbohydrates on postprandial blood glucose levels. For this purpose, we compared the effects of different carbohydrates with well-established glycemic indexes. We orally administered (gavage) increasing amounts (0.2, 0.4, 0.6, 0.8, and 1.0 g/kg) of sucrose and lactose to rats which had been fasted for 6 h or 15 h, respectively. In part of the experiments we administered frutose (gavagem). Three different models were compared for measuring postprandial blood glucose levels: a) evaluation of interstitial glucose concentrations by using a real time continuous glucose monitoring system; b) evaluation of glucose levels in blood obtained from the rat tail; c) evaluation of serum glucose levels in blood collected after decapitation. Our results showed that blood obtained from the tails of 15-h fasted rats was the best model in which to evaluate the effect of carbohydrates on postprandial blood glucose levels.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000400761
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| Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
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| Relação: |
10.1590/s1984-82502016000400021
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.52 n.4 2016
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| Direitos: |
info:eu-repo/semantics/openAccess
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