| Registro completo |
| Provedor de dados: |
BJPS
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| País: |
Brazil
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| Título: |
A suppository-base-matrix tablet for time-dependent colon-specific delivery system
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| Autores: |
Zou,Meijuan
Wang,Caixia
Zhang,Xuezhu
Xu,Tao
Han,Jiarong
Zhang,Xiao
Cheng,Gang
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| Data: |
2014-09-01
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| Ano: |
2014
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| Palavras-chave: |
Inflammatory bowel disease
Lonicera japonica Thunb/extract
Suppository/colon-specific delivery system
Drugs/colon-specific delivery system
Tablets/colon-specific delivery system
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| Resumo: |
Our research has focused on the main design features and release performances of time-dependent colon-specific (TDCS) delivery tablets, which relies on the relative constancy that is observed in the small intestinal transit time of dosage forms. But inflammatory bowel disease（IBD）can affect the transit time, and usually results in watery stool. Compared to the TDCS and wax-matrix TDCS tablet, a promising time-dependent colon-specific delivery system was investigated. In our study, a suppository-base-matrix coated tablet was evaluated. Water soluble suppository-base helps the expansion of tablet, facilitates uniform film dissolution and achives high osmotic pressure. Combining the expansion of carboxymethyl starch sodium (CMS-Na) and the moisture absorption of NaCl, the coated TDCS tablet obtained a burst and targeted drug delivery system. A very good correlation between in vitro drug release and in vivo outcome was observed. This TDCS coated tablet provides a promising strategy to control drug release to the desired lower gastrointestinal region.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300535
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| Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
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| Relação: |
10.1590/S1984-82502014000300012
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.50 n.3 2014
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| Direitos: |
info:eu-repo/semantics/openAccess
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