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Provedor de dados:  BJPS
País:  Brazil
Título:  Antidiabetic and antihyperlipidemic effects of Dillenia indica (L.) leaves extract
Autores:  Kumar,Sunil
Kumar,Vipin
Prakash,Om
Data:  2011-06-01
Ano:  2011
Palavras-chave:  Dillenia indica/antidiabetic effects
Dillenia indica/experimental study
Dillenia indica/antihyperlipidemic effects
Dillenia indica/experimental study
Antidiabetics/experimental study
Serum transaminase
Serum cholesterol
HDL-cholesterol level
Resumo:  The present study was carried out to evaluate antidiabetic and antihyperlipidemic effects of Dillenia indica methanolic leaves extracts in streptozotocin induced diabetic Wistar rats by administering graded oral doses (250 and 500 mg/kg body weight) for 21 days. The extract showed significant antidiabetic activity (p<0.001). Furthermore, the decreased body weight of rats was significantly improved after extract treatments. Daily oral treatment with the extract for 21 days to diabetic rats, also resulted in significant reduction in serum cholesterol, triglycerides and serum transaminase levels but HDL-cholesterol level was found to be improved (p<0.001) as compared to the diabetic control group. The extract treatment also showed to enhance serum insulin level in diabetic rats as compared to the diabetic control group. In conclusion, D. indica leaf extract might be useful for diabetes mellitus management and other abnormalities associated with this metabolic disorder.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000200018
Editor:  Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação:  10.1590/S1984-82502011000200018
Formato:  text/html
Fonte:  Brazilian Journal of Pharmaceutical Sciences v.47 n.2 2011
Direitos:  info:eu-repo/semantics/openAccess
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