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Provedor de dados: |
BJPS
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País: |
Brazil
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Título: |
Anti-diabetic effect of betulinic acid on streptozotocin-nicotinamide induced diabetic male mouse model
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Autores: |
Birgani,Golshan Arzani
Ahangarpour,Akram
Khorsandi,Layasadat
Moghaddam,Hadi Fathi
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Data: |
2018-01-01
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Ano: |
2018
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Palavras-chave: |
Betulinic acid
Diabetes
Mouse
Streptozotocin-nicotinamide.
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Resumo: |
ABSTRACT Diabetes is a metabolic disease caused by abnormal insulin secretion or action. In the present study, the effects of betulinic acid (BA, a triterpene) are evaluated on glucose, α-amylase and plasma insulin levels, insulin resistance and the histopathology of pancreatic islets in streptozotocin-nicotinamide (STZ-NA) diabetic mice. Seventy adult male NMRI mice were randomly divided into seven groups: control, sham, diabetic, diabetic treated with BA (10, 20 and 40 mg/kg) and diabetic treated with metformin (200 mg/kg). Diabetes was induced in mice by intraperitoneal injection of streptozotocin 50 mg/kg after a dose of nicotinamide 120 mg/kg. Two weeks after treatment with BA, blood samples were collected for measuring glucose, α-amylase and insulin levels, and the pancreas was isolated for histopathology evaluation. Diabetes reduced the number and diameter of pancreatic islets, and increased α-amylase and insulin resistance. BA treatment reduced blood glucose, α-amylase and improved insulin sensitivity as well as pancreas histopathology. In addition, BA showed stronger effects on the pancreatic histology and insulin resistance compared to the metformin group.
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Tipo: |
Info:eu-repo/semantics/article
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Idioma: |
Inglês
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Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200621
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Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
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Relação: |
10.1590/s2175-97902018000217171
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Formato: |
text/html
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Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.54 n.2 2018
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Direitos: |
info:eu-repo/semantics/openAccess
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