| Registro completo |
| Provedor de dados: |
60
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| País: |
Brazil
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| Título: |
Assessment of anti-diabetic activity of a novel hydrazine-thiazole derivative: in vitro and in vivo method
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| Autores: |
Resende,Marina Ferrara de
Lino,Cleudiomar Inácio
Souza-Fagundes,Elaine Maria de
Rettore,João Vitor Paes
Oliveira,Renata Barbosa de
Labanca,Renata Adriana
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| Data: |
2019-01-01
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| Ano: |
2019
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| Palavras-chave: |
Oxidative stress
Diabetes mellitus
Curcumin
Thiazole derivatives
Dietary supplement
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| Resumo: |
Diabetes mellitus is a chronic disease resulting in oxidative stress that promotes tissue damage. The appearance of this disease is highly related to lifestyle and food of the population, being of great interest to search for a dietary supplement that can also act by reducing oxidative alterations. Based on the broad range of biological activity of thiazole derivatives, this work aimed to evaluate the in vitro antioxidant activity of a novel hydrazine-thiazole derivative and studies in vivo. In in vivo experiments, the liver extracts of healthy and diabetic Wistar rats were used, with analysis to determine the enzymatic activity of SOD, CAT, GPx, and GR, and determination of lipid peroxidation. Finally, in the blood of these animals, biochemical parameters were evaluated. Statistical evidence of changes caused in liver enzymes and liquid peroxidation was not detected; however, these parameters were also not changed between control groups with and without diabetes. On the other hand, concerning biochemical parameters, significant differences were detected in uric acid, alkaline phosphatase, ALT, and urea, indicating a possible antioxidant protective role of such substances in the liver and kidney of diabetic animals that could be acting by means other than that commonly reported in the literature.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100509
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| Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
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| Relação: |
10.1590/s2175-97902019000118218
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.55 2019
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| Direitos: |
info:eu-repo/semantics/openAccess
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