Registro completo |
Provedor de dados: |
BJPS
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País: |
Brazil
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Título: |
Design, preparation and in vitro characterizations of fluconazole loaded nanostructured lipid carriers
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Autores: |
Fernandes,Amanda Velinna
Pydi,Chinna Raja
Verma,Ruchi
Jose,Jobin
Kumar,Lalit
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Data: |
2020-01-01
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Ano: |
2020
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Palavras-chave: |
Fluconazole
NLCs
Nanostructured lipid carriers
Fungal infections
Full factorial design
Design of experiment
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Resumo: |
Present study was aimed to prepare and characterize fluconazole loaded nanostructured lipid carriers (FLZ-NLCs) for the treatment of fungal infections. Fungal infections are tremendously widespread and are the often faced dermatological condition worldwide. FLZ-NLCs was prepared by ultrasonication emulsion technique using stearic acid (SA) as solid lipid, castor oil as liquid lipid and tween 20 as a surfactant. The mean diameter of optimized FLZ-NLCs were found to be 359.15 ± 9.83 nm. The drug content and entrapment efficiency of NLCs was found to be 102.97 ± 7.45% and 87 ± 0.59%, respectively. In vitro drug release studies of FLZ-NLCs showed 37.34 ± 2.08% drug release over a period of 72 h. The above studies confirmed the prepared FLZ-NLCs may be useful for the treatment of fungal infections.
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Tipo: |
Info:eu-repo/semantics/article
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Idioma: |
Inglês
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Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100524
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Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
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Relação: |
10.1590/s2175-97902019000318069
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Formato: |
text/html
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Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.56 2020
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Direitos: |
info:eu-repo/semantics/openAccess
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