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Provedor de dados:  BJPS
País:  Brazil
Título:  Vasodilator activity of extracts of field Alpinia purpurata (Vieill) K: Schum and A. zerumbet (Pers.) Burtt et Smith cultured in vitro
Autores:  Victório,Cristiane Pimentel
Kuster,Ricardo Machado
Moura,Roberto Soares de
Lage,Celso Luiz Salgueiro
Data:  2009-09-01
Ano:  2009
Palavras-chave:  Alpinia purpurata (Vieill) K. Schum./pharmacognosy
A. zerumbet (Pers.) Burtt et Smith./pharmacognosy
Natural vasodilators/experimental studies
Plant extracts/vasodilator action
Plant tissue/culture
Endothelium-dependent
Flavonoids
Medicinal Plant
Plant growth/regulators
Zingiberaceae
Resumo:  Nowadays, the high blood pressure is one of the main causes of death and cardiovascular diseases. Vasodilator drugs are frequently used to treat arterial hypertension. Experiments were undertaken to determine whether hydroalcoholic extracts obtained from leaves of field-grown Alpinia purpurata and A. zerumbet cultured in vitro under different plant growth regulators induce a vasodilator effect on Wistar rat mesenteric vascular bed pre-contracted with norepinephrine. Plant extracts were able to induce a long-lasting endothelium-dependent vasodilation. Efficiency on activity of A. purpurata reached 87% at concentration of 60 μg. The extract of A. zerumbet maintained in medium containing IAA, induced the relaxation (17.4%) at 90 μg, as compared to the control (MS0) that showed a better vasodilator effect (60%). These results are in agreement with the quantification of phenolic compounds in the extracts, which were 50% lower for those plants cultured in IAA. A. purpurata was assayed for the first time in relation to its vasodilator activity. This paper showed a strong probability of correlation between the pharmacological activities of A. purpurata with their content in phenolic compounds.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000300017
Editor:  Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação:  10.1590/S1984-82502009000300017
Formato:  text/html
Fonte:  Brazilian Journal of Pharmaceutical Sciences v.45 n.3 2009
Direitos:  info:eu-repo/semantics/openAccess
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