| Registro completo |
| Provedor de dados: |
BJPS
|
| País: |
Brazil
|
| Título: |
Laurus nobilis L.: assessment of the cytotoxic and genotoxic potential of aqueous extracts by micronucleus and Allium cepa assays
|
| Autores: |
Silva,Mayara Christine
Matos,Aline Ferreira
Santos,Hataânderson Luíz Cabral dos
Gomes,Jennifer Vieira
Pastura,Danilo Giovanni Narciso
Pereira,Gabriela Lopes
Rocha,Ellen Borges da
Larangeira,Mayara de Jesus Costa
Alves,Raphael Santiago
Bastos,Leonardo de Oliveira
Borba,Helcio Resende
Lima,Viviane Moreira de
|
| Data: |
2020-01-01
|
| Ano: |
2020
|
| Palavras-chave: |
Laurus nobilis
Allium cepa
Micronucleus
Genotoxicity
Cytotoxicity
|
| Resumo: |
Laurus nobilis L. is a large shrub belonging to the Lauracea family. Its leaves are widely used for food seasoning as well as in folk medicine. Various studies have demonstrated the antiproliferative, antifungal and antibacterial effects of Laurus nobilis, but no studies have investigated the genotoxic effect of the aqueous extract of the plant. The objective of this study was to analyze the genotoxic potential of an aqueous extract of leaves, using the Allium cepa assay and mouse peripheral blood cell micronucleus test. The results showed that the extract did not have any genotoxic activity, but cytotoxic activity was observed in the two experimental models used. The extract had an antiproliferative effect, detected through the reduction of the mitotic index and the polychromatic/normochromatic erythrocyte (PCE/NCE) ratio. The tests also demonstrated a large number of cells undergoing apoptosis and with nuclear abnormalities related to cell death processes. These results can be explained by the presence of phenolic compounds, saponins, flavonoids and alkaloids, detected in the phytochemical analysis of the extract. Therefore, the extract from L. nobilis in the form generally used by the population does not pose risks related to its genotoxic potential, and also contains components with apoptotic and antigenotoxic potential.
|
| Tipo: |
Info:eu-repo/semantics/article
|
| Idioma: |
Inglês
|
| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100534
|
| Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
|
| Relação: |
10.1590/s2175-97902019000318302
|
| Formato: |
text/html
|
| Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.56 2020
|
| Direitos: |
info:eu-repo/semantics/openAccess
|
|
