| Registro completo |
| Provedor de dados: |
BJPS
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| País: |
Brazil
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| Título: |
Hypotensive effect and endothelium-dependent vascular action of leaves of Alpinia purpurata (Vieill) K. Schum
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| Autores: |
Silva,Alessandra Tesch da
Lima,Ewelyne Miranda de
Caliman,Isabela Faco
Porto,Leonardo Luiz Souza
Nascimento,Andrews Marques do
Kalil,Iêda Carneiro
Lenz,Dominik
Bissoli,Nazaré Souza
Endringer,Denise Coutinho
Andrade,Tadeu Uggere de
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| Data: |
2014-06-01
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| Ano: |
2014
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| Palavras-chave: |
Alpinia
Alpinia purpurata/phytochemistry
Alpinia purpurata/ethanolic extract/vascular reactivity
Alpinia purpurata/ethanolic extract/acute hypotensive effect
Flavonoids/quantification
Polyphenols/quantification
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| Resumo: |
The aims of this study were to evaluate the chemical profile, vascular reactivity, and acute hypotensive effect (AHE) of the ethanolic extract of leaves of Alpinia purpurata (Vieill) K. Schum (EEAP). Its chemical profile was evaluated using HPLC-UV, ICP-OES, and colorimetric quantification of total flavonoids and polyphenols. The vascular reactivity of the extract was determined using the mesenteric bed isolated from WKY. AHE dose-response curves were obtained for both EEAP and inorganic material isolated from AP (IAP) in WKY and SHR animals. Cytotoxic and mutagenic safety levels were determined by the micronucleus test. Rutin-like flavonoids were quantified in the EEAP (1.8 ± 0.03%), and the total flavonoid and polyphenol ratios were 4.1 ± 1.8% and 5.1 ± 0.3%, respectively. We observed that the vasodilation action of EEAP was partially mediated by nitric oxide (·NO). The IAP showed the presence of calcium (137.76 ± 4.08 μg mg-1). The EEAP and IAP showed an AHE in WKY and SHR animals. EEAP did not have cytotoxic effects or cause chromosomic alterations. The AHE shown by EEAP could result from its endothelium-dependent vascular action. Rutin-like flavonoids, among other polyphenols, could contribute to these biological activities, and the calcium present in EEAP could act in a synergistic way.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000200309
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| Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
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| Relação: |
10.1590/S1984-82502014000200010
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.50 n.2 2014
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| Direitos: |
info:eu-repo/semantics/openAccess
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