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Provedor de dados:  60
País:  Brazil
Título:  Methods of acute biological assays in guinea-pigs for the study of toxicity and innocuity of drugs and chemicals
Autores:  Ko,Gui Mi
Rosenkranz,Adela
Bertoncini,Clélia Rejane Antonio
Jurkiewicz,Neide Hyppolito
Franco,Mirian Ghiraldini
Jurkiewicz,Aron
Data:  2010-06-01
Ano:  2010
Palavras-chave:  Acute biological assays/methods
Cosmetics/toxicity
Cosmetics/experimental study
Cosmetics/innocuity
Drugs/toxicity
Drugs/experimental study
Drugs/innocuity
Chemical substances/toxicity
Chemical substances/experimental study
Dermal irritability/experimental study
Resumo:  In this study, 602 samples were tested by the following assays performed at the animal facilities (Cedeme) of the Federal University of São Paulo (UNIFESP): 385 for dermal irritability, 90 for ocular irritability (discontinued in 1995), 31 for systemic toxicity by injection, 26 for oral acute toxicity, 15 for toxicity by intracutaneous injection, 15 for skin sensitization, 15 for toxicity of serum and vaccines for human use, 14 for toxicity by intramuscular implantation, 7 for pyrogens, 2 for acute dermal toxicity, and 2 for irritation of mucous membrane. The following agents were tested: cosmetics and related substances (42.0%), chemicals used in industry (32.9%), plastics, rubber, and other polymers (15.9%), agrotoxics (4.0%), medicines (2.7%), and vaccines (2.5%). In the present description, emphasis was given to tests of dermal irritability and sensitization. This work was conducted entirely in animal facilities, according to our general belief that animal facilities at universities, while considering ethic principles and sanitary, genetic, nutritional, and pathophysiological controls, also require laboratories specialized in areas such as transgenics, cryopreservation, ambiental physiology, functional genomics, alternative models, and mainly activities and research on methods in toxicology, as focused in this study.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000200012
Editor:  Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação:  10.1590/S1984-82502010000200012
Formato:  text/html
Fonte:  Brazilian Journal of Pharmaceutical Sciences v.46 n.2 2010
Direitos:  info:eu-repo/semantics/openAccess
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