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Provedor de dados:  BJPS
País:  Brazil
Título:  Toxicological and pharmacological evaluation of Discaria americana Gillies & Hook (Rhamnaceae) in mice
Autores:  Silva,Eliane Regina da
Diedrich,Denise
Bolzan,Rodrigo Cordeiro
Giacomelli,Sandro Rogério
Data:  2012-06-01
Ano:  2012
Palavras-chave:  Discaria americana/phamacognosy
Medicinal plants
Discaria americana/toxicological analysis
Discaria americana/acute toxicity
Discaria americana/subacute toxicity
Discaria americana/anxiolytic effect
Discaria americana/antinociceptive effect
Resumo:  Medicinal plants (e.g. Discaria americana) have been used by populations for centuries. However, popular use is not enough to validate these plants as safe and effective medicinal products. The present study sought to evaluate the acute and subacute toxicity as well as the anxiolytic and antinociceptive effects of D. americana root bark and aerial parts extracts in mice. In acute toxicity studies, mice were treated with single intraperitoneal doses of the aforementioned extracts. Subacute toxicity studies were performed by oral administration of the extracts over 14 days. Anxiolytic studies consisted of the elevated plus maze method, and antinociceptive studies were based on the hot plate test. The LD50 value for D. americana aerial parts extract was established at >500 mg/kg, and for the root bark extract, 400 mg/kg. D. americana aerial parts extract produced anxiolytic (250 mg/kg) and antinociceptive effects (125, 200 and 250 mg/kg). Conversely, D. americana root bark extract showed neither anxiolytic nor antinociceptive effects in mice.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000200011
Editor:  Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação:  10.1590/S1984-82502012000200011
Formato:  text/html
Fonte:  Brazilian Journal of Pharmaceutical Sciences v.48 n.2 2012
Direitos:  info:eu-repo/semantics/openAccess
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