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Provedor de dados:  60
País:  Brazil
Título:  Synthesis and characterization of a cysteine xyloglucan conjugate as mucoadhesive polymer
Autores:  Bhalekar,Mangesh
Sonawane,Savita
Shimpi,Shamkant
Data:  2013-06-01
Ano:  2013
Palavras-chave:  Mucoadhesion
Thiomer
Xyloglucan
L-cysteine HCl
Resumo:  The aim of this study was to improve the mucoadhesive potential of xyloglucan polymer by the covalent attachment of cysteine as thiol moiety. The parent polymer xyloglucan was chemically modified by introducing sulphydryl bearing compound L-cysteine HCl. Different batches of xyloglucan-cysteine conjugates were prepared at varying reaction pH (2-6) and evaluated for optimum thiol incorporation, disulphide group content, swelling behavior, rheological properties and mucoadhesive properties. The obtained conjugates characterized in vitro by quantification of immobilized thiol groups; showed maximum thiol incorporation on xyloglucan (7.67 ± 0.14 %) at pH 5. The disulphide group content was found maximum (2.83 ± 0.12) at pH 6. The water uptake at end of 4 h was 5.0 for xyloglucan and was found to decrease in thiolated derivatives with increase in thiolation. Mucoadhesion studies revealed that mucoadhesion of xyloglucan-cysteine conjugate increased more than twice compared to the unmodified polymer. The viscosity of thiomer was more than that of xyloglucan because of formation of disulphide bonds.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000200010
Editor:  Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação:  10.1590/S1984-82502013000200010
Formato:  text/html
Fonte:  Brazilian Journal of Pharmaceutical Sciences v.49 n.2 2013
Direitos:  info:eu-repo/semantics/openAccess
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