| Registro completo |
| Provedor de dados: |
BJPS
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| País: |
Brazil
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| Título: |
Formulation and in vitro evaluation of taste-masked oro-dispersible dosage form of diltiazem hydrochloride
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| Autores: |
Jagdale,Swati Changdeo
Gawali,Vaibhav Uttam
Kuchekar,Bhanudas Shankar
Chabukswar,Aniruddha Rajaram
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| Data: |
2011-12-01
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| Ano: |
2011
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| Palavras-chave: |
Diltiazem hydrochloride
Cyclodextrin
Drugs/taste-masking
Freeze-drying
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| Resumo: |
Diltiazem hydrochloride is a calcium channel blocker generally indicated for the treatment of angina and hypertension, and it is extensively metabolized due to the hepatic metabolism. Formulation of diltiazem hydrochloride into an oro-dispersible dosage form can provide fast relief with higher bioavailability. The bitter taste of the drug should be masked to formulate it in a palatable form. In the present work, an attempt was made to mask the taste by complexation technique, with a formulation into an oro-dispersible dosage form, using superdisintegrants Doshion P544, crospovidone (CP) and sodium starch glycolate (SSG). The complexes of diltiazem hydrochloride with β-CD (1:1 molar ratio) were prepared by kneading, co-evaporation, co-grounding, freeze-drying and melting methods. Phase solubility showed stability constant 819.13M-1. Prepared inclusion complexes were evaluated for taste masking and characterized by I.R, XRD, DSC. Using the drug β-CD complex, oro-dispersible tablets were prepared and evaluated for hardness, friability, weight variation, thickness, disintegrating time (DT), dissolution rate and taste. Formulations with 4 % Doshion, 8 % CP and 4 % SSG showed DT of 0.54, 0.35 and 1.23 minutes, respectively.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000400028
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| Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
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| Relação: |
10.1590/S1984-82502011000400028
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.47 n.4 2011
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| Direitos: |
info:eu-repo/semantics/openAccess
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