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Provedor de dados:  60
País:  Brazil
Título:  A novel approach in mucoadhesive drug delivery system to improve zidovudine intestinal permeability
Autores:  Pedreiro,Liliane Neves
Cury,Beatriz Stringhetti Ferreira
Chaud,Marco Vinícius
Gremião,Maria Palmira Daflon
Data:  2016-12-01
Ano:  2016
Palavras-chave:  Zidovudine
Solid dispersion
Mucoadhesion
P-glycoprotein
Intestinal permeability.
Resumo:  ABSTRACT Zidovudine (AZT) mucoadhesive solid dispersions (SD) were prepared using a sodium starch glycolate (SSG) and hypromellose phthalate (HPMCP) mixtures as carrier to enhance the intestinal permeability and bioavailability of zidovudine. SDs were prepared using the co-precipitation method followed by solvent evaporation and characterized according to their physicochemical properties such as particle size, crystallinity, thermal behavior, and liquid uptake ability. In vitro drug dissolution, mucoadhesiveness and AZT intestinal permeability were also determined. Thermal behavior and X-ray diffraction patterns demonstrated the amorphous state of AZT in SD systems. The HPMCP polymer restricted the liquid uptake ability in the acid medium; however, this property significantly increased with higher pH values. SDs allowed drug dissolution to occur in a controlled manner. HPMCP decreased the dissolution rates in the acid medium. The mucoadhesiveness of SDs was demonstrated and the permeability of AZT carried in solid dispersions was significantly improved. The effect of the SD carrier polymers on blocking efflux pump can be an important approach to improve the bioavailability of AZT.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000400715
Editor:  Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação:  10.1590/s1984-82502016000400016
Formato:  text/html
Fonte:  Brazilian Journal of Pharmaceutical Sciences v.52 n.4 2016
Direitos:  info:eu-repo/semantics/openAccess
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