| Registro completo |
| Provedor de dados: |
BJPS
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| País: |
Brazil
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| Título: |
Effects of Cymbopogon winterianus Jowitt ex Bor essential oil on the growth and morphogenesis of Trichophyton mentagrophytes
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| Autores: |
Pereira,Fillipe de Oliveira
Wanderley,Paulo Alves
Viana,Fernando Antônio Cavalcanti
Lima,Rita Baltazar de
Sousa,Frederico Barbosa de
Santos,Sócrates Golzio dos
Lima,Edeltrudes de Oliveira
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| Data: |
2011-03-01
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| Ano: |
2011
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| Palavras-chave: |
Trichophyton mentagrophytes/mycology
Dermatophytosis Cymbopogon winterianus/essential oil
Dermatophytosis Cymbopogon winterianus/antifungal activity
Dermatophytes
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| Resumo: |
Trichophyton mentagrophytes is a fungus causative agent of dermatophytosis, affecting humans worldwide. This has driven the search for products for the treatment of these infections. Accordingly, the aim of this study was to investigate the antifungal activity of the Cymbopogon winterianus essential oil against T. mentagrophytes. The antifungal tests consisted of antifungal screening, determination of MIC and MFC, analysis of the essential oil's effects on mycelial growth, germination of fungal spores, fungal viability, morphogenesis, cell wall (test with sorbitol) and cell membrane (cell leakage test) of T. mentagrophytes. Upon screening, the oil inhibited all strains, with zones of growth inhibition of 24-28 mm in diameter. The MIC was 312 μg/mL and CFM was 2500 μg/mL for almost all the strains tested. There were morphological changes in the conidia group, form and pigmentation of hyphae. The antifungal action of the product does not involve the cell wall and its action may involve the fungal plasma membrane. It is concluded that C. winterianus essential oil constitutes a potential antifungal product, especially for the treatment of dermatophytosis.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000100018
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| Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
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| Relação: |
10.1590/S1984-82502011000100018
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.47 n.1 2011
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| Direitos: |
info:eu-repo/semantics/openAccess
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