| Registro completo |
| Provedor de dados: |
BJPS
|
| País: |
Brazil
|
| Título: |
Ethanolic extract of Passiflora edulis Sims leaves inhibits protein glycation and restores the oxidative burst in diabetic rat macrophages after Candida albicans exposure
|
| Autores: |
Martins,Carolina Fernandes Ribas
Salles,Bruno César Corrêa
Brigagão,Maisa Ribeiro Pereira Lima
Rodrigues,Maria Rita
Ferreira,Eric Batista
Duarte,Stella Maris da Silveira
Paula,Fernanda Borges de Araujo
|
| Data: |
2015-12-01
|
| Ano: |
2015
|
| Palavras-chave: |
Passiflora edulis Sims/pharmacognosy
Passiflora edulis Sims/ethanolic extract/effects
Blood glucose
Protein glycation
Reactive oxygen species
Diabetes/treatment/experimental study
Medicinal plants.
|
| Resumo: |
abstract This study was conducted to evaluate the effects of the ethanolic extract of Passiflora edulis leaves on blood glucose, protein glycation, NADPH oxidase activity and macrophage phagocytic capacity after Candida albicans exposure in diabetic rats. The Passiflora edulis Sims leaves were dried to 40°C, powdered, extracted by maceration in 70% ethanol, evaporated under reduced pressure and lyophilised. The biochemical tests performed were total phenolic content (TP) as determined by the Folin-Ciocalteu assay, trapping potential DPPH assay and total iron-reducing potential. Diabetes was induced by alloxan injection. Protein glycation was determined by AGE and fructosamine serum concentrations. Extract-treated diabetic animals demonstrated lower fructosamine concentrations compared with the diabetic group. Our results suggest that ethanolic Passiflora edulis Sims leaf extraction may have beneficial effects on diabetes and may improve glycaemic control in diabetic rats.
|
| Tipo: |
Info:eu-repo/semantics/article
|
| Idioma: |
Inglês
|
| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000400869
|
| Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
|
| Relação: |
10.1590/S1984-82502015000400013
|
| Formato: |
text/html
|
| Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.51 n.4 2015
|
| Direitos: |
info:eu-repo/semantics/openAccess
|
