| Registro completo |
| Provedor de dados: |
Ciência Rural
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| País: |
Brazil
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| Título: |
Can Triamcinolone acetonide, platelet-rich plasma, and pentosan polysulfate sodium induce oxidative stress in cultured equine chondrocytes?
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| Autores: |
Palma,Heloisa Einloft
Gallio,Miguel
Silva,Gabriele Biavaschi da
Cantarelli,Camila
Wolkmer,Patrícia
Salazar,Rodrigo Fernando dos Santos
Wergutz,Julien
Krause,Luciana Maria Fontanari
Krause,Alexandre
Brass,Karin Erica
Corte,Flavio Desessards De La
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| Data: |
2019-01-01
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| Ano: |
2019
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| Palavras-chave: |
Antioxidant enzymes
Catalase
Glutathione peroxidase
Lipid peroxidation
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| Resumo: |
ABSTRACT: Progressive deterioration and loss of articular cartilage are the final degenerative events common to osteoarthritis (OA). Reactive oxygen species (ROS) play an important role in this chondrocyte catabolic activity, leading to cell death and matrix components breakdown. Intra-articular corticosteroid injections such as triamcinolone acetonide have been used to control pain and inflammation associated with OA. New treatments for OA, platelet-rich plasma and pentosan polysulphate sodium have also been used and further investigations are necessary to determine their safety in joint cells. In this in vitro study, the use of these three substances (triamcinolone acetonide, platelet-rich plasma, and pentosan polysulphate sodium) in healthy chondrocytes did not alter the antioxidant status when compared to control groups, indicating that they could be considered safe in healthy conditions.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019000700602
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| Editor: |
Universidade Federal de Santa Maria
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| Relação: |
10.1590/0103-8478cr20180263
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| Formato: |
text/html
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| Fonte: |
Ciência Rural v.49 n.7 2019
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| Direitos: |
info:eu-repo/semantics/openAccess
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