| Registro completo |
| Provedor de dados: |
Ciência Rural
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| País: |
Brazil
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| Título: |
Physicochemical characterization and evaluation of in vitro and in vivo toxicity of goldenberry extract nanoemulsion
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| Autores: |
Silva,Suelen Santos da
Bazana,Maiara Taís
Deus,Cassandra de
Machado,Marina Lopes
Cordeiro,Larissa Marafiga
Soares,Félix Alexandre Antunes
Libreloto,Daniele Rubert Nogueira
Rolim,Clarice Madalena Bueno
Menezes,Cristiano Ragagnin de
Codevilla,Cristiane Franco
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| Data: |
2019-01-01
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| Ano: |
2019
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| Palavras-chave: |
Physalis peruviana
Nanoemulsion
Citotoxicity
C. elegans.
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| Resumo: |
ABSTRACT: Oil-in-water (O/W) nanoemulsion containing goldenberry extract was elaborated using a high-energy ultrasonic bath method. Physicochemical characterization of the formulation was carried out by determining pH, mean droplet diameter, polydispersity index (PDI) and zeta potential. Nanoemulsion toxicity was assessed using in vitro assays with tumor and non-tumor cell lines, and in vivo using Caenorhabditis elegans. The pH of the nanoemulsion was 3.84, the mean droplet diameter was 268 ± 7 nm, PDI 0.113 and zeta potential -13.94 mV. Results of the cytotoxicity assays employing non-tumor cells indicated that the extract associated or not with nanoemulsion maintained cell viability at different concentrations tested. In the assays using tumor lineage, it is observed that the nanoemulsion containing the extract had higher antitumor activity than the free extract. As for the in vivo tests, there was no change in the survival rate of the worms.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019000800754
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| Editor: |
Universidade Federal de Santa Maria
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| Relação: |
10.1590/0103-8478cr20190015
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| Formato: |
text/html
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| Fonte: |
Ciência Rural v.49 n.8 2019
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| Direitos: |
info:eu-repo/semantics/openAccess
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