| Registro completo |
| Provedor de dados: |
Ciência Rural
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| País: |
Brazil
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| Título: |
Identification of multi-drug resistance gene (MDR1) in equine ileum
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| Autores: |
Natalini,Cláudio Corrêa
Linardi,Renata Lehn
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| Data: |
2006-02-01
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| Ano: |
2006
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| Palavras-chave: |
Molecular biology
Opioids
Equine
Gene
MDR1
ABCB1
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| Resumo: |
P-glycoprotein (P-gp) is a membrane transporter encoded in the Multi-drug Resistance (MDR1) gene expressed in several normal tissues and over expressed in tumor cells. P-gp was already identified in different species but not yet in equine. MDR1 gene and P-gp are able to interfere with bioavailability and disposition of several drugs, altering pharmacokinetic and pharmacodinamic of drugs. The presence of the MDR1 and P-gp in the central nervous system blocks the entry of certain drugs in this tissue and reduces drug absorption and enhances drug elimination when P-gp and MDR1 are presented in the gastrointestinal tract. This study showed that the MDR1 gene is present in equine ileum. Future studies on the impact of the P-glycoprotein encoded gene MDR1 on drugs pharmacologic effects in horses are granted.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782006000100048
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| Editor: |
Universidade Federal de Santa Maria
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| Relação: |
10.1590/S0103-84782006000100048
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| Formato: |
text/html
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| Fonte: |
Ciência Rural v.36 n.1 2006
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| Direitos: |
info:eu-repo/semantics/openAccess
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