| Registro completo |
| Provedor de dados: |
Ciência Rural
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| País: |
Brazil
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| Título: |
Osteoprogenitor cells can enhance early bone formation in critical bone defects in dogs
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| Autores: |
Alves,Endrigo Gabellini Leonel
Serakides,Rogéria
Rosado,Isabel Rodrigues
Paez,Omar Leonardo Aristizabal
Varon,Jéssica Alejandra Castro
Machado,Felipe Nemer
Fukushima,Fabíola Bono
Góes,Alfredo Miranda
Rezende,Cleuza Maria de Faria
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| Data: |
2017-01-01
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| Ano: |
2017
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| Palavras-chave: |
Bone regeneration
Orthopedics
Cellular therapy
Fracture non-union
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| Resumo: |
ABSTRACT: The aim of this study was to evaluate the effect of osteoprogenitor cells derived from mesenchymal stem cells from adipose tissue (OC-AD-MSCs), and differentiated into osteoblasts, in the treatment of critical bone defects in dogs. Adipose tissue derived mesenchymal stem cells (AD-MSCs) were subjected to osteogenic differentiation for 21 days and used in the treatment of bone defects in dogs radius. Either three experimental groups were bone defects treated with OC-AD-MSCs (OC), defects filled with autogenous bone (Control- C +), or empty defects (Control- C -). Bone regeneration was assessed by radiology, densitometry, and histomorphometry. The area of new bone formation was higher in the OC group compared to the control group (C-) on postoperative day 15. Defects treated with OC-AD-MSCs showed greater neovascularization than the other two groups at 90 days. We concluded that treatment with OC-AD-MSCs increased the area of new bone formation 15 days after surgery; however, it didn’t complete the bone union in critical bone defects in the radius of dogs at 90 days.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782017000700604
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| Editor: |
Universidade Federal de Santa Maria
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| Relação: |
10.1590/0103-8478cr20151109
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| Formato: |
text/html
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| Fonte: |
Ciência Rural v.47 n.7 2017
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| Direitos: |
info:eu-repo/semantics/openAccess
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