| Registro completo |
| Provedor de dados: |
Ciência Rural
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| País: |
Brazil
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| Título: |
Autologous bone marrow transplantation in a dog with lymphoma: a clinical study
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| Autores: |
Cápua,Maria Luísa Buffo de
Coleta,Flávia Eiras Dela
Miotto,Mariana Rodrigues
Calazans,Sabryna Gouveia
Godoy,Aline Vieira
Nakage,Ana Paula Massae
Lisbão,Carolina Bonduki Sales
Daleck,Carlos Roberto
Santana,Aureo Evangelista
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| Data: |
2009-04-01
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| Ano: |
2009
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| Palavras-chave: |
Canine
Cutaneous lymphoma
Autologous bone marrow transplant
Chemotherapy
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| Resumo: |
The objective of this study is to provide the first report of bone marrow transplantation (BMT) in dogs in Brazil. A Rottweiler with cutaneous lymphoma was submitted to a twelve-week Madison-Wisconsin chemotherapy protocol followed by autologous bone marrow transplantation. For this, 10mL kg-1 of bone marrow was collected simultaneously from both iliac crests and cryopreserved in a freezer at -80°C. The conditioning step was performed by administering cyclophosphamide by intravenous route at 400mg m-2. Bone marrow was reinfused after defrosting in a water bath at 37°C. Bone marrow nucleated cell counts before and after freezing, showed a small relative loss of nucleated cells (35.10 and 31.80x10³µL-1 , respectively). Cyclophosphamide induced neutropenia which was reverted by a granulocyte colony-stimulating factor (G-CSF) capable of stimulating hematopoetic reconstitution. On the day 360 after transplant the patient was found to be in complete remission. This study indicates that autologous BMT in a dog with lymphoma submitted to myelosuppressive chemotherapy was potentially safe and effective.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782009000200045
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| Editor: |
Universidade Federal de Santa Maria
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| Relação: |
10.1590/S0103-84782008005000087
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| Formato: |
text/html
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| Fonte: |
Ciência Rural v.39 n.2 2009
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| Direitos: |
info:eu-repo/semantics/openAccess
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