| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
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| País: |
Brazil
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| Título: |
A rare case of Acute Lymphocytic Leukemia (ALL) presenting with double Philadelphia chromosome: relapse or secondary leukemia?
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| Autores: |
Campos,Mireille Guimarães Vaz de
Chauffaille,Maria de Lourdes L. Ferrari
Rodrigues,Celso Arrais
Krum,Everson A.
Yamamoto,Mihoko
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| Data: |
2003-01-01
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| Ano: |
2003
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| Palavras-chave: |
Relapsed acute lymphocytic leukemia
Double Philadelphia chromosome
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| Resumo: |
The Philadelphia chromosome is observed in 5% of pediatric acute lymphocytic leukemia (ALL) and in 25% to 50% of adult ALL cases, and is associated with poor prognosis. Double Ph in a hyperdiploid karyotype is common in chronic myeloid leukemia (CML), but rarely found in ALL. We report here the case of a girl diagnosed with ALL at 7 years of age. After treatment with the pediatric protocol BFM 83 for ALL, she stayed in continuous complete remission for nine years. At age 19, she was re-admitted with a white blood cell count of 6.8 x 10(9)/L with 3% blasts, and a platelet count of 65 x 109/L. Bone marrow aspirate showed 92.6% lymphoid blast cells, and chromosome analysis after G-banding revealed the karyotype 51,XX,+?5,t(9;22)(q34.1;q11.2),+16,+20,+21,+der(22)t(9;22)(q34.1;q11.2) [10]/46,XX[1]. FISH analysis for the BCR/ABL fusion showed 56% of interphase cells with two fusion signals, 30% with one, and 6% with three. Double Ph is rare in relapsed leukemia, and the possibility of secondary leukemia cannot be ruled out.
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| Tipo: |
Info:eu-repo/semantics/other
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572003000300006
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| Editor: |
Sociedade Brasileira de Genética
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| Relação: |
10.1590/S1415-47572003000300006
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| Formato: |
text/html
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| Fonte: |
Genetics and Molecular Biology v.26 n.3 2003
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| Direitos: |
info:eu-repo/semantics/openAccess
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