| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
|
| País: |
Brazil
|
| Título: |
Perforin gene PRF1 c.900C> T polymorphism and HIV-1 vertical transmission
|
| Autores: |
Zupin,Luisa
Polesello,Vania
Kamada,Anselmo Jiro
Gratton,Rossella
Segat,Ludovica
Kuhn,Louise
Crovella,Sergio
|
| Data: |
2019-09-01
|
| Ano: |
2019
|
| Palavras-chave: |
PRF1
Perforin
HIV-1 susceptibility
|
| Resumo: |
Abstract Perforin-1, a component of the immune system, is able to control Human Immunodeficiency Virus-1 (HIV-1) replication and could be involved in HIV-1 mother-to-child transmission (MTCT). This study aims at evaluating the role of the c.900C > T PRF1 gene (encoding for perforin-1) polymorphism (rs885822) in HIV-1 MTCT. The PRF1 c.900C > T polymorphism was genotyped in 331 children from Zambia using a Taqman probe on a Real Time PCR platform. The PRF1 c.900C > T C/T genotype was more frequent among HIV-1 exposed but non-infected children than in HIV-1 positive cases, and the results were confirmed among children infected during breastfeeding. PRF1 c.900C > T correlated with protection against HIV-1 MTCT, suggesting its role in HIV-1 vertical transmission.
|
| Tipo: |
Info:eu-repo/semantics/other
|
| Idioma: |
Inglês
|
| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000400574
|
| Editor: |
Sociedade Brasileira de Genética
|
| Relação: |
10.1590/1678-4685-gmb-2018-0243
|
| Formato: |
text/html
|
| Fonte: |
Genetics and Molecular Biology v.42 n.3 2019
|
| Direitos: |
info:eu-repo/semantics/openAccess
|
