| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
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| País: |
Brazil
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| Título: |
Frequencies of BCR-ABL1 fusion transcripts among Sudanese chronic myeloid leukaemia patients
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| Autores: |
Osman,Emad-Aldin I.
Hamad,Kamal
Elmula,Imad M. Fadl
Ibrahim,Muntaser E.
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| Data: |
2010-01-01
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| Ano: |
2010
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| Palavras-chave: |
BCR-ABL
Chronic myeloid leukemia
Ph chromosome
Sudanese
RT-PCR
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| Resumo: |
The incidence of one or other rearrangement in chronic myeloid leukemia (CML) patients varies in different reported series. In this study we report the frequencies of BCR-ABL1 fusion transcript variants studied in 43 CML patients from Sudan. The study includes 46 Sudanese patients, three of which negative for the BCR-ABL1 fusion transcript. More than half of 43 positive patients showed b2a2 fusion transcript (53.5%), while (41.9%) showed b3a2 transcript and the remaining (4.6%) coexpression of b3a2/ b2a2 and b3a2/b2a2/e19a2. We detected neither coexpression of p210/p190 nor e1a2 alone. Male patients showed a tendency to express b2a2, while female tende to express b3a2 (p = 0.017). Moreover, a single nucleotide polymorphism was detected in BCR exon 13 in one out of four patients and this patient showed only b2a2 expression. In conclusion, we observed a significant correlation between sex and type of BCR-ABL1 transcript, an observation that deserves further investigation.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000200005
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| Editor: |
Sociedade Brasileira de Genética
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| Relação: |
10.1590/S1415-47572010005000037
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| Formato: |
text/html
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| Fonte: |
Genetics and Molecular Biology v.33 n.2 2010
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| Direitos: |
info:eu-repo/semantics/openAccess
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