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Provedor de dados:  Genet. Mol. Biol.
País:  Brazil
Título:  Silencing of the integrin-linked kinase gene suppresses the proliferation, migration and invasion of pancreatic cancer cells (Panc-1)
Autores:  Zhu,Xiang-Yu
Data:  2012-01-01
Ano:  2012
Palavras-chave:  E-cadherin
Epithelial-mesenchymal transition (EMT)
Integrin-linked kinase (ILK)
Panc-1 cell line
RNA interference (RNAi)
Resumo:  Integrin-linked kinase (ILK) is an ankyrin repeat-containing serine-threonine protein kinase that is involved in the regulation of integrin-mediated processes such as cancer cell proliferation, migration and invasion. In this study, we examined the effect of a lentivirus-mediated knockdown of ILK on the proliferation, migration and invasion of pancreatic cancer (Panc-1) cells. Immunohistochemical staining showed that ILK expression was enhanced in pancreatic cancer tissue. The silencing of ILK in human Panc-1 cells led to cell cycle arrest in the G0/G1 phase and delayed cell proliferation, in addition to down-regulating cell migration and invasion. The latter effects were mediated by up-regulating the expression of E-cadherin, a key protein in cell adhesion. These findings indicate that ILK may be a new diagnostic marker for pancreatic cancer and that silencing ILK could be a potentially useful therapeutic approach for treating pancreatic cancer.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Editor:  Sociedade Brasileira de Genética
Relação:  10.1590/S1415-47572012005000028
Formato:  text/html
Fonte:  Genetics and Molecular Biology v.35 n.2 2012
Direitos:  info:eu-repo/semantics/openAccess

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