| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
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| País: |
Brazil
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| Título: |
Myeloperoxidase gene-463G > a polymorphism and premature coronary artery disease
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| Autores: |
Zhong,Chen
Quanzhong,Yin
Genshan,Ma
Hua,Zhang
Ruolong,Zheng
Jiahong,Wang
Chunheng,Gao
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| Data: |
2009-01-01
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| Ano: |
2009
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| Palavras-chave: |
Premature coronary artery disease
Myeloperoxidase
Protective genetic polymorphism
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| Resumo: |
We investigated the association between myeloperoxidase gene -463G > A polymorphism and premature coronary artery disease (CAD) in two Chinese population samples: 229 patients and 230 controls. Genotypes were determined by ligase detection reaction-polymerase chain reaction sequencing and the grouping technique. We found lower frequencies of both the A/A genotype and the A allele in patients (p < 0.05). Multivariate logistic regression showed that the risk of premature CAD in subjects carrying the AA genotype was reduced by 83% in relation to individuals carrying the G/G genotype (OR = 0.172, 95% CI: 0.057-0.526, p = 0.002). Our results indicate that -463G > A polymorphism of the myeloperoxidase gene is associated with premature CAD in Chinese individuals, suggesting that the AA genotype is a protective factor against premature CAD.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000200009
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| Editor: |
Sociedade Brasileira de Genética
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| Relação: |
10.1590/S1415-47572009005000035
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| Formato: |
text/html
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| Fonte: |
Genetics and Molecular Biology v.32 n.2 2009
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| Direitos: |
info:eu-repo/semantics/openAccess
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