| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
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| País: |
Brazil
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| Título: |
The lactase persistence genotype is a protective factor for the metabolic syndrome
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| Autores: |
Friedrich,Deise C.
Andrade,Fabiana M de
Fiegenbaum,Marilu
Almeida,Silvana de
Mattevi,Vanessa S.
Callegari-Jacques,Sidia M.
Hutz,Mara H.
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| Data: |
2014-12-01
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| Ano: |
2014
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| Palavras-chave: |
Metabolic syndrome
Lactase persistence
Hypolactasia
Lactose
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| Resumo: |
The Metabolic Syndrome (MetS) is defined as a pattern of metabolic disturbances, which include central obesity, insulin resistance and hyperglycemia, dyslipidemia, and hypertension. Milk has been promoted as a healthy beverage that can improve the management of MetS. Most human adults, however, down-regulate the production of intestinal lactase after weaning. Lactase encoded by the LCT gene is necessary for lactose digestion. The -13910C > T SNP (rs4988235) is responsible for the lactase persistence phenotype in European populations. We herein investigated whether the lactase persistence genotype is also associated with the MetS in subjects from a Brazilian population of European descent. This study consisted of 334 individuals (average age of 41 years) genotyped by PCR-based methods for the -13910C > T SNP. Clinical data were assessed and the genotypes were tested for their independent contribution to the MetS using chi-square tests and multiple logistic regression analysis. Univariate analyses showed that hypertension and MetS prevalence were higher in individuals with the lactase non-persistence genotype than in lactase persistence subjects. Furthermore, lactase persistence was associated with a lower risk for MetS (OR = 0.467; 95% CI 0.264-0.824; p = 0.009). These results suggest that LCT genotypes can be a valuable tool for the management of MetS treatment.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572014000500001
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| Editor: |
Sociedade Brasileira de Genética
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| Relação: |
10.1590/S1415-47572014005000012
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| Formato: |
text/html
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| Fonte: |
Genetics and Molecular Biology v.37 n.4 2014
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| Direitos: |
info:eu-repo/semantics/openAccess
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