| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
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| País: |
Brazil
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| Título: |
Silencing of the integrin-linked kinase gene suppresses the proliferation, migration and invasion of pancreatic cancer cells (Panc-1)
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| Autores: |
Zhu,Xiang-Yu
Liu,Ning
Liu,Wei
Song,Shao-Wei
Guo,Ke-Jian
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| Data: |
2012-01-01
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| Ano: |
2012
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| Palavras-chave: |
E-cadherin
Epithelial-mesenchymal transition (EMT)
Integrin-linked kinase (ILK)
Panc-1 cell line
RNA interference (RNAi)
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| Resumo: |
Integrin-linked kinase (ILK) is an ankyrin repeat-containing serine-threonine protein kinase that is involved in the regulation of integrin-mediated processes such as cancer cell proliferation, migration and invasion. In this study, we examined the effect of a lentivirus-mediated knockdown of ILK on the proliferation, migration and invasion of pancreatic cancer (Panc-1) cells. Immunohistochemical staining showed that ILK expression was enhanced in pancreatic cancer tissue. The silencing of ILK in human Panc-1 cells led to cell cycle arrest in the G0/G1 phase and delayed cell proliferation, in addition to down-regulating cell migration and invasion. The latter effects were mediated by up-regulating the expression of E-cadherin, a key protein in cell adhesion. These findings indicate that ILK may be a new diagnostic marker for pancreatic cancer and that silencing ILK could be a potentially useful therapeutic approach for treating pancreatic cancer.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000300022
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| Editor: |
Sociedade Brasileira de Genética
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| Relação: |
10.1590/S1415-47572012005000028
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| Formato: |
text/html
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| Fonte: |
Genetics and Molecular Biology v.35 n.2 2012
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| Direitos: |
info:eu-repo/semantics/openAccess
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