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Provedor de dados:  Genet. Mol. Biol.
País:  Brazil
Título:  From yeast to humans: Understanding the biology of DNA Damage Response (DDR) kinases
Autores:  Cussiol,José Renato Rosa
Soares,Bárbara Luísa
Oliveira,Francisco Meirelles Bastos de
Data:  2020-01-01
Ano:  2020
Palavras-chave:  Yeast
Genome instability
DNA damage response
Cell cycle checkpoint
Kinase
Resumo:  Abstract The DNA Damage Response (DDR) is a complex network of biological processes that protect cells from accumulating aberrant DNA structures, thereby maintaining genomic stability and, as a consequence, preventing the development of cancer and other diseases. The DDR pathway is coordinated by a signaling cascade mediated by the PI3K-like kinases (PIKK) ATM and ATR and by their downstream kinases CHK2 and CHK1, respectively. Together, these kinases regulate several aspects of the cellular program in response to genomic stress. Much of our understanding of these kinases came from studies performed in the 1990s using yeast as a model organism. The purpose of this review is to present a historical perspective on the discovery of the DDR kinases in yeast and the importance of this model for the identification and functional understanding of their mammalian orthologues.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000200302
Editor:  Sociedade Brasileira de Genética
Relação:  10.1590/1678-4685-gmb-2019-0071
Formato:  text/html
Fonte:  Genetics and Molecular Biology v.43 n.1 suppl.1 2020
Direitos:  info:eu-repo/semantics/openAccess
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