| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
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| País: |
Brazil
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| Título: |
VDR polymorphisms influence immunological response in HIV-1+ individuals undergoing antiretroviral therapy
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| Autores: |
Silva,Ronaldo Celerino da
Alves,Neyla Maria Pereira
Pereira,Jorge José de Souza
Coelho,Antonio Victor Campos
Arraes,Luiz Cláudio
Brandão,Lucas André Cavalcanti
Crovella,Sergio
Silva,Jaqueline de Azevêdo
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| Data: |
2019-06-01
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| Ano: |
2019
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| Palavras-chave: |
VDR
HIV-1
ARVs
SNPs
CD4 recovery
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| Resumo: |
Abstract Vitamin D exerts an immuno-modulatory activity on several immune system cells through the vitamin D receptor (VDR). Herein, we verified that age and a therapeutic regimen containing protease inhibitors are associated with failures in antiretroviral therapies (ARVs). In addition, we assessed whether a VDR SNP (rs11568820: C allele and CC genotype) and GC (rs2228570-rs11568820) allelic combinations are associated with immunological failure (p < 0.05). Our findings suggest a possible role of VDR SNPs on immunological failure in HIV-1+ individuals undergoing regular ARVs.
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| Tipo: |
Info:eu-repo/semantics/other
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000300351
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| Editor: |
Sociedade Brasileira de Genética
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| Relação: |
10.1590/1678-4685-gmb-2017-0289
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| Formato: |
text/html
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| Fonte: |
Genetics and Molecular Biology v.42 n.2 2019
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| Direitos: |
info:eu-repo/semantics/openAccess
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