| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
|
| País: |
Brazil
|
| Título: |
NS3 protease from flavivirus as a target for designing antiviral inhibitors against dengue virus
|
| Autores: |
Natarajan,Satheesh
|
| Data: |
2010-01-01
|
| Ano: |
2010
|
| Palavras-chave: |
Antiviral inhibitor
Drug discovery
Multifunctional protein
NS3
Protease
|
| Resumo: |
The development of novel therapeutic agents is essential for combating the increasing number of cases of dengue fever in endemic countries and among a large number of travelers from non-endemic countries. The dengue virus has three structural proteins and seven non-structural (NS) proteins. NS3 is a multifunctional protein with an N-terminal protease domain (NS3pro) that is responsible for proteolytic processing of the viral polyprotein, and a C-terminal region that contains an RNA triphosphatase, RNA helicase and RNA-stimulated NTPase domain that are essential for RNA replication. The serine protease domain of NS3 plays a central role in the replicative cycle of dengue virus. This review discusses the recent structural and biological studies on the NS2B-NS3 protease-helicase and considers the prospects for the development of small molecules as antiviral drugs to target this fascinating, multifunctional protein.
|
| Tipo: |
Info:eu-repo/semantics/article
|
| Idioma: |
Inglês
|
| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000200002
|
| Editor: |
Sociedade Brasileira de Genética
|
| Relação: |
10.1590/S1415-47572010000200002
|
| Formato: |
text/html
|
| Fonte: |
Genetics and Molecular Biology v.33 n.2 2010
|
| Direitos: |
info:eu-repo/semantics/openAccess
|
