| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
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| País: |
Brazil
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| Título: |
Effects of artichoke (Cynara scolymus) leaf and bloom head extracts on chemically induced DNA lesions in Drosophila melanogaster
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| Autores: |
Jacociunas,Laura Vicedo
Dihl,Rafael Rodrigues
Lehmann,Mauricio
Ferraz,Alexandre de Barros Falcão
Richter,Marc François
Silva,Juliana da
Andrade,Heloísa Helena Rodrigues de
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| Data: |
2014-01-01
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| Ano: |
2014
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| Palavras-chave: |
Artichoke
Drosophila melanogaster
Recombinogenicity
SMART
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| Resumo: |
The genotoxicity of bloom head (BHE) and leaf (LE) extracts from artichoke (Cynara scolymus L.), and their ability to modulate the mutagenicity and recombinogenicity of two alkylating agents (ethyl methanesulfonate - EMS and mitomycin C - MMC) and the intercalating agent bleomycin (BLM), were examined using the somatic mutation and recombination test (SMART) in Drosophila melanogaster. Neither the mutagenicity nor the recombinogenicity of BLM or MMC was modified by co- or post-treatment with BHE or LE. In contrast, co-treatment with BHE significantly enhanced the EMS-induced genotoxicity involving mutagenic and/or recombinant events. Co-treatment with LE did not alter the genotoxicity of EMS whereas post-treatment with the highest dose of LE significantly increased this genotoxicity. This enhancement included a synergistic increase restricted to somatic recombination. These results show that artichoke extracts promote homologous recombination in proliferative cells of D. melanogaster.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572014000100015
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| Editor: |
Sociedade Brasileira de Genética
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| Relação: |
10.1590/S1415-47572014000100015
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| Formato: |
text/html
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| Fonte: |
Genetics and Molecular Biology v.37 n.1 2014
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| Direitos: |
info:eu-repo/semantics/openAccess
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