| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
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| País: |
Brazil
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| Título: |
Spi2 gene polymorphism is not associated with recurrent airway obstruction and inflammatory airway disease in thoroughbred horses
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| Autores: |
Silva,Aline Correa da
Brass,Karin Erica
Loreto,Elgion da Silva
Vinocur,Myriam Elizabeth
Pozzobon,Ricardo
Azevedo,Marcos da Silva
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| Data: |
2011-01-01
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| Ano: |
2011
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| Palavras-chave: |
Horse
Respiratory disease
SSCP
Alpha-1-antitrypsin
Serpin
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| Resumo: |
The aim was to detect the presence of polymorphisms at exons 1, 2, 3 and 4 of the Spi2 gene, and evaluate a possible association between them and recurrent airway obstruction (RAO) or inflammatory airway disease (IAD) in thoroughbred horses, through single-strand conformational-polymorphism (SSCP) screening. Although polymorphism was not detected in exons 1, 2 and 3, three alleles and six genotypes were identified in exon 4. The frequencies of allele A (0.6388) and genotype AA (0.3888) were higher in horses affected by RAO, although no association was found between polymorphism and horses with either RAO or IAD.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000300015
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| Editor: |
Sociedade Brasileira de Genética
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| Relação: |
10.1590/S1415-47572011005000017
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| Formato: |
text/html
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| Fonte: |
Genetics and Molecular Biology v.34 n.3 2011
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| Direitos: |
info:eu-repo/semantics/openAccess
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