| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
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| País: |
Brazil
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| Título: |
Approaches for in silico finishing of microbial genome sequences
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| Autores: |
Kremer,Frederico Schmitt
McBride,Alan John Alexander
Pinto,Luciano da Silva
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| Data: |
2017-09-01
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| Ano: |
2017
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| Palavras-chave: |
Microbial genetics
Molecular microbiology
Genomics
Microbiology
Draft genomes
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| Resumo: |
Abstract The introduction of next-generation sequencing (NGS) had a significant effect on the availability of genomic information, leading to an increase in the number of sequenced genomes from a large spectrum of organisms. Unfortunately, due to the limitations implied by the short-read sequencing platforms, most of these newly sequenced genomes remained as “drafts”, incomplete representations of the whole genetic content. The previous genome sequencing studies indicated that finishing a genome sequenced by NGS, even bacteria, may require additional sequencing to fill the gaps, making the entire process very expensive. As such, several in silico approaches have been developed to optimize the genome assemblies and facilitate the finishing process. The present review aims to explore some free (open source, in many cases) tools that are available to facilitate genome finishing.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000400553
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| Editor: |
Sociedade Brasileira de Genética
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| Relação: |
10.1590/1678-4685-gmb-2016-0230
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| Formato: |
text/html
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| Fonte: |
Genetics and Molecular Biology v.40 n.3 2017
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| Direitos: |
info:eu-repo/semantics/openAccess
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