| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
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| País: |
Brazil
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| Título: |
The insulin polymorphism -23Hph increases the risk for type 1 diabetes mellitus in the Romanian population
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| Autores: |
Cimponeriu,Danut
Apostol,Pompilia
Radu,Irina
Craciun,Anne Marie
Serafinceanu,Cristian
Toma,Mihai
Panaite,Cristian
Cheta,Dan
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| Data: |
2010-01-01
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| Ano: |
2010
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| Palavras-chave: |
Insulin -23Hph
Insulin-like growth factor 2 Apa
Diabetes
Obesity
Case-control study
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| Resumo: |
The insulin -23Hph and IGF2 Apa polymorphisms were genotyped in Romanian patients with T1DM (n = 204), T2DM (n = 215) or obesity (n = 200) and normoponderal healthy subjects (n = 750). The genotypes of both polymorphisms were distributed in concordance with Hardy-Weinberg equilibrium in all groups. The -23Hph AA genotype increased the risk for T1DM (OR: 3.22, 95%CI: 2.09-4.98, p < 0,0001), especially in patients without macroalbuminuria (OR: 4.32, 95%CI: 2.54-7.45, p < 0,0001). No other significant association between the alleles or genotypes of insulin -23Hph and IGF2 Apa and diabetes or obesity was identified.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000400003
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| Editor: |
Sociedade Brasileira de Genética
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| Relação: |
10.1590/S1415-47572010005000074
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| Formato: |
text/html
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| Fonte: |
Genetics and Molecular Biology v.33 n.4 2010
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| Direitos: |
info:eu-repo/semantics/openAccess
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