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Provedor de dados:  Genet. Mol. Biol.
País:  Brazil
Título:  Alterations in DNA repair gene expression and their possible regulation in rat-liver regeneration
Autores:  Wang,Gai-Ping
Xu,Cun-Shuan
Data:  2011-01-01
Ano:  2011
Palavras-chave:  Partial hepatectomy
Rat genome array
DNA repair genes
Liver regeneration
Resumo:  Rapidly proliferating tissue may require enhanced DNA repair capacity in order to avoid fixation of promutagenic DNA lesions to mutations. Partial hepatectomy (PH) triggers cell proliferation during liver regeneration (LR). However, little is known on how DNA repair genes change and how they are regulated at the transcriptional level during LR. In the present study, the Rat Genome 230 2.0 array was used to detect the expression profiles of DNA repair genes during LR, and differential expression of selected genes was confirmed by real-time RT-PCR. 69 DNA repair genes were found to be associated with LR, more than half of which distributed in a cluster characterized by a gradual increase at 24-72h and then returning to normal. The expression of base excision repair- and transcription-coupled repair-related genes was enhanced in the early and intermediate phases of LR, whereas the expression of genes related to HR, NHEJ and DNA cross-link repair, as well as DNA polymerases and related accessory factors, and editing or processing nucleases, were mainly enhanced in the intermediate phase. The expression changes of genes in DNA damage response were complicated throughout the whole LR. Our data also suggest that the expression of most DNA repair genes may be regulated by the cell cycle during LR.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000200023
Editor:  Sociedade Brasileira de Genética
Relação:  10.1590/S1415-47572011005000013
Formato:  text/html
Fonte:  Genetics and Molecular Biology v.34 n.2 2011
Direitos:  info:eu-repo/semantics/openAccess
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