| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
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| País: |
Brazil
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| Título: |
Association between human papillomavirus (HPV) DNA and micronuclei in normal cervical cytology
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| Autores: |
Cassel,Ana Paula Rebelo
Barcellos,Regina Bones
Silva,Cláudia Maria Dornelles da
Almeida,Sabrina Esteves de Matos
Rossetti,Maria Lucia Rosa
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| Data: |
2014-06-01
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| Ano: |
2014
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| Palavras-chave: |
Human papillomavirus
Micronucleus
Cytology
High-risk HPV
Southern Brazil
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| Resumo: |
The aim of the present study was to investigate the association between HPV-DNA and micronucleus (MN) frequency in women with normal cervical cytology. A total of 158 normal cervical smears were analyzed cytologically. The HPV genome was amplified using the GP5+/bioGP6+ consensus primers. HPV-DNA of high-risk types 16, 18, 31, 33, 39, 45 and 59 were also investigated. Of the 158 samples, 20 (12.7%) and 47 (29.7%) were positive for HPV-DNA and MN, respectively. Evidence for MN was found in 11 out of 20 (55%) HPV-DNA positive samples and in 36 out of 138 (26.1%) HPV-DNA negative ones. MN presence was significantly higher in HPV-DNA positive samples (p = 0.016). On the other hand, the absence of MN observed in a considerable number of HPV-DNA negative samples (102) may be of great value in predicting the absence of HPV. The mean age of HPV-DNA positive women (34.2 ± 12.6) was significantly lower than the mean age of HPV-DNA negative women (43.9 ± 13.7) (p = 0.003). Infection by one or multiple HPV types was found in 11 out of 20 (55.0%) and 9 out of 20 (45.0%) samples, respectively. The evaluation of MN using cervical smears collected for cytology tests could, thus, be used as additional information to monitor a population's exposure to HPV.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572014000300007
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| Editor: |
Sociedade Brasileira de Genética
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| Relação: |
10.1590/S1415-47572014005000010
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| Formato: |
text/html
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| Fonte: |
Genetics and Molecular Biology v.37 n.2 2014
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| Direitos: |
info:eu-repo/semantics/openAccess
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