| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
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| País: |
Brazil
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| Título: |
Up-regulation of RIP1 and IPS-1 in chronic HBV infected patients
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| Autores: |
Safari-Arababadi,Minoo
Modarressi,Mohammad Hossein
Arababadi,Mohammad Kazemi
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| Data: |
2019-06-01
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| Ano: |
2019
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| Palavras-chave: |
Innate immunity
Hepatitis B
RIP1
IPS-1
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| Resumo: |
Abstract IPS-1 and RIP1 are the main downstream molecules of RIG1 and MDA5, as intracytoplasmic receptors, which are the main receptors involved in recognition of internal and external viral double-stranded RNA. In this project, mRNA levels of IPS-1 and RIP1 were investigated in the peripheral blood immune cells of chronic hepatitis B (CHB) patients. IPS-1 and RIP1 mRNA levels were measured in 60 CHB patients and 120 healthy subjects, using RT-qPCR technique. A significant increase in expression levels of IPS-1 and RIP1 was found in patients when compared to healthy individuals. There was no correlation between IPS-1 and RIP1expression levels with the serum levels of hepatitis B e-Antigen (HBeAg) and liver enzymes in patients. Based on the results, it seems that IPS-1 and RIP1 can participate in the induction of low chronic inflammation, which is a main cause of liver cirrhosis and hepatocellular carcinoma.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000300337
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| Editor: |
Sociedade Brasileira de Genética
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| Relação: |
10.1590/1678-4685-gmb-2018-0071
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| Formato: |
text/html
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| Fonte: |
Genetics and Molecular Biology v.42 n.2 2019
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| Direitos: |
info:eu-repo/semantics/openAccess
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