| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
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| País: |
Brazil
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| Título: |
Association of serum lipid components and obesity with genetic ancestry in an admixed population of elderly women
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| Autores: |
Lins,Tulio C.
Pires,Alause S.
Paula,Roberta S.
Moraes,Clayton F.
Vieira,Rodrigo G.
Vianna,Lucy G.
Nobrega,Otávio T.
Pereira,Rinaldo W.
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| Data: |
2012-01-01
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| Ano: |
2012
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| Palavras-chave: |
Dyslipidemia
Genetic ancestry
Lipid profile
Obesity
Postmenopausal women
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| Resumo: |
The prevalence of metabolic disorders varies among ethnic populations and these disorders represent a critical health care issue for elderly women. This study investigated the correlation between genetic ancestry and body composition, metabolic traits and clinical status in a sample of elderly women. Clinical, nutritional and anthropometric data were collected from 176 volunteers. Genetic ancestry was estimated using 23 ancestry-informative markers. Pearsons correlation test was used to examine the relationship between continuous variables and an independent samples t-test was used to compare the means of continuous traits within categorical variables. Overall ancestry was a combination of European (57.49%), Native American (25.78%) and African (16.73%). Significant correlations were found for European ancestry with body mass index (r = 0.165; p = 0.037) and obesity (mean difference (MD) = 5.3%; p = 0.042). African ancestry showed a significant correlation with LDL (r = 0.159, p = 0.035), VLDL (r = -0.185; p = 0.014), hypertriglyceridemia (MD = 6.4%; p = 0.003) and hyperlipidemia (MD = 4.8%; p = 0.026). Amerindian ancestry showed a significant correlation with triglyceride levels (r = 0.150; p = 0.047) and hypertriglyceridemia (MD = 4.5%; p = 0.039). These findings suggest that genetic admixture may influence the etiology of lipid metabolism-related diseases and obesity in elderly women.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000400005
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| Editor: |
Sociedade Brasileira de Genética
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| Relação: |
10.1590/S1415-47572012005000047
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| Formato: |
text/html
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| Fonte: |
Genetics and Molecular Biology v.35 n.3 2012
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| Direitos: |
info:eu-repo/semantics/openAccess
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