| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
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| País: |
Brazil
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| Título: |
Lack of an association between SNPs within the cholinergic receptor genes and smoking behavior in a Czech post-MONICA study
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| Autores: |
Hubacek,Jaroslav A.
Lanska,Vera
Adamkova,Vera
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| Data: |
2014-12-01
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| Ano: |
2014
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| Palavras-chave: |
Cholinergic receptors
Polymorphism
Smoking
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| Resumo: |
Smoking has a significant heritable component of approximately 30-60%. Recent genome wide association studies have identified single nucleotide polymorphisms (SNPs) within the nicotinic cholinergic receptor subunits 3 (rs578776), 5 (rs16969968) and β3 (rs6474412), which are associated with nicotine dependence in Western European populations. To analyze the association in a Czech population, we genotyped 1,191 males and 1,368 females (post-MONICA study). The WHO protocol was used to examine smoking status and the number of cigarettes smoked per day. There were 32.1% current and 27.6% past smokers among the males and 22.5% current and 13.8% past smokers among the females. We have not confirmed the original results: the SNPs rs16969968 (p = 0.07), rs578776 (p = 0.16) and rs6474412 (p = 0.76) were not associated with smoking status (never-smokers vs. ever-smokers) in the entire population, if a codominant model of analysis was used. This result was valid for both the male and female subpopulations if analyzed separately and adjusted for age. Finally, in ever-smokers, the number of cigarettes smoked per day was also independent of different genotypes, regardless of which polymorphism (and gender) was analyzed (the lowest p value was 0.49). The association between the cholinergic receptors - nicotinic subunits (-3, -5 and -ß3), and smoking behavior may be population-dependent.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572014000500004
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| Editor: |
Sociedade Brasileira de Genética
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| Relação: |
10.1590/S1415-47572014005000023
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| Formato: |
text/html
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| Fonte: |
Genetics and Molecular Biology v.37 n.4 2014
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| Direitos: |
info:eu-repo/semantics/openAccess
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