| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
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| País: |
Brazil
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| Título: |
Genotoxic potential of Cotinus coggygria Scop. (Anacardiaceae) stem extract in vivo
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| Autores: |
Matic,Sanja
Stanic,Snezana
Bogojevic,Desanka
Solujic,Slavica
Grdovic,Nevena
Vidakovic,Melita
Mihailovic,Mirjana
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| Data: |
2011-01-01
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| Ano: |
2011
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| Palavras-chave: |
Comet assay
Cotinus coggygria
Extract
Genotoxic effect
SLRL
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| Resumo: |
The intention was to evaluate the possible in vivo genotoxic potential in different cell-types, of a methanol extract obtained from the plant stem of Cotinus coggygria Scop., using the sex-linked recessive lethal (or SLRL) test and alkaline comet assay. The SLRL test, revealed the genotoxic effect of this extract in postmeiotic and premeiotic germ-cell lines. The comet assay was carried out on rat liver and bone marrow at 24 and 72 h after intraperitoneal administration. For genotoxic evaluation, three concentrations of the extract were tested, viz., 500, 1000 and 2000 mg/kg body weight (bw), based on the solubility limit of the extract in saline. Comet tail moment and total scores in the group treated with 500 mg/kg bw, 24 and 72 h after treatment, were not significantly different from the control group, whereas in the groups of animals, under the same conditions, but with 1000 and 2000 mg/kg bw of the extract, scores were statistically so. A slight decrease in the comet score and tail moment observed in all the doses in the 72 h treatment, gave to understand that DNA damage induced by Cotinus coggygria extract decreased with time. The results of both tests revealed the genotoxic effect of Cotinus coggygria under our experimental conditions.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000200022
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| Editor: |
Sociedade Brasileira de Genética
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| Relação: |
10.1590/S1415-47572011005000001
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| Formato: |
text/html
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| Fonte: |
Genetics and Molecular Biology v.34 n.2 2011
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| Direitos: |
info:eu-repo/semantics/openAccess
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