| Registro completo |
| Provedor de dados: |
International Journal of Morphology
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| País: |
Chile
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| Título: |
Inmunohistochemical Expression of PCNA, p53 and bcl-2 in Pleomorphic Adenomas
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| Autores: |
Gordón-Núñez,Manuel Antonio
Godoy,Gustavo Pina
Soares,Rosilene Calazans
Souza,Lélia Batista de
Freitas,Roseana de Almeida
Queiroz,Lélia María Guedes
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| Data: |
2008-09-01
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| Ano: |
2008
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| Palavras-chave: |
Pleomorphic adenoma
Salivary gland tumour
P53
PCNA
Bcl-2
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| Resumo: |
The aim of the study was to determine the immunohistochemical expression of the PCNA, p53 and bcl-2 proteins in pleomorphic adenomas.onineteen specimens of pleomorphic adenomas were selected for analysis by the streptavidin-biotin-peroxidase method with antibodies againstp53, PCNA and bcl-2 proteins. It was observedweak labeling for p53 in 12 cases (63.1%) andforPCNA in 8 (42.1%). With respect to the bcl-2 labeling index,ono expression of this protein was detected in 12 cases, corresponding to 63.1% of the sample. Based on these findings, it was concluded that p53 and PCNA can favor the proliferative activity of pleomorphic adenomas, whereas bcl-2 probably doesonot effectively particípate in the pathogenesis of this tumor.
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| Tipo: |
Journal article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000300010
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| Editor: |
Sociedad Chilena de Anatomía
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| Formato: |
text/html
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| Fonte: |
International Journal of Morphology v.26 n.3 2008
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