| Registro completo |
| Provedor de dados: |
J. Venom. Anim. Toxins incl. Trop. Dis.
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| País: |
Brazil
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| Título: |
Heterologous fibrin sealant derived from snake venom: from bench to bedside – an overview
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| Autores: |
Ferreira Jr,Rui Seabra
Barros,Luciana Curtolo de
Abbade,Luciana Patrícia Fernandes
Barraviera,Silvia Regina Catharino Sartori
Silvares,Maria Regina Cavariani
Pontes,Leticia Gomes de
Santos,Lucilene Delazari dos
Barraviera,Benedito
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| Data: |
2017-01-01
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| Ano: |
2017
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| Palavras-chave: |
Fibrin sealant
Snake venom
Cryoprecipitate coagulum
Thrombin-like enzyme
Buffaloes
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| Resumo: |
Abstract Hemostatic and adhesive agents date back to World War II, when homologous fibrin sealant came onto scene. Considering that infectious diseases can be transmitted via human blood, a new heterologous fibrin sealant was standardized in the 1990s. Its components were a serine protease (a thrombin-like enzyme) extracted from the venom of Crotalus durissus terrificus snakes and a fibrinogen-rich cryoprecipitate extracted from the blood of Bubalus bubalis buffaloes. This new bioproduct has been used as a coagulant, sealant, adhesive and recently as a candidate scaffold for mesenchymal stem cells and bone and cartilage repair. This review discusses the composition of a new heterologous fibrin sealant, and cites published articles related to its preclinical applications aiming at repairing nervous system traumas and regenerating bone marrow. Finally, we present an innovative safety trial I/II that found the product to be a safe and clinically promising candidate for treating chronic venous ulcers. A multicenter clinical trial, phase II/III, with a larger number of participants will be performed to prove the efficacy of an innovative biopharmaceutical product derived from animal venom.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100204
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| Editor: |
Centro de Estudos de Venenos e Animais Peçonhentos
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| Relação: |
10.1186/s40409-017-0109-8
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| Formato: |
text/html
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| Fonte: |
Journal of Venomous Animals and Toxins including Tropical Diseases v.23 2017
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| Direitos: |
info:eu-repo/semantics/openAccess
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